Autologous Blood Vessels Engineered from Peripheral Blood Sample
نویسندگان
چکیده
منابع مشابه
Autologous blood vessels engineered from peripheral blood sample.
OBJECTIVE Although many efforts have been made to generate small-diameter (< or =5mm) vascular grafts by means of tissue engineering, improvement in patency and functionality still remains a great challenge. It is our hypothesis that to achieve long-term functionality and patency, not only the complete lining with endothelial cells but also full biocompatibility is essential. DESIGN The aim w...
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Although vascular bypass grafting remains the mainstay for revascularization for ischemic heart disease and peripheral vascular disease, many patients do not have healthy vessels suitable for harvest. Thus, prosthetic grafts made of synthetic polymers were developed, but their use is limited to high-flow/low-resistance conditions because of poor elasticity, low compliance, and thrombogenicity o...
متن کاملBlood vessels engineered from human cells.
Human vascular tissue engineering has progressed substantially over the past decade. Issues remain as to the optimum culture scaffold and cell source that should be used for arterial regeneration. In addition, limitations in replicative life span of adult human cells as compared with young animal cells have made human vascular tissue engineering more challenging. Despite these obstacles, severa...
متن کاملGene therapy in tissue-engineered blood vessels.
Cardiovascular disease is the leading cause of morbidity and mortality in Western society. More than 1 million arterial bypass procedures are performed annually in the United States, where either autologous veins or synthetic grafts are used to replace arteries in the coronary or peripheral circulation. Tissue engineering of blood vessels from autologous cells has the potential to produce biolo...
متن کاملFunctional tissue-engineered blood vessels from bone marrow progenitor cells.
OBJECTIVE Stem cells have significant potential for development of cell-based therapeutics for cardiovascular tissue regeneration. METHODS We developed a novel method for isolating smooth muscle cells (SMC) from ovine bone marrow using a tissue-specific promoter and fluorescence-activated cell sorting. RESULTS As compared to vascular SMC, bone marrow-derived smooth muscle progenitor cells (...
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ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 2007
ISSN: 1078-5884
DOI: 10.1016/j.ejvs.2006.08.008